An improved one-pot cost-effective synthesis of N, N-disubstituted carbamoyl halides and derivatives

K Adeppa, DC Rupainwar…

Index: Adeppa; Rupainwar; Misra, Krishna Canadian Journal of Chemistry, 2010 , vol. 88, # 12 p. 1277 - 1280

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Citation Number: 4

Abstract

A convenient one-pot procedure is reported for preparing N, N-disubstituted carbamoyl chlorides by using chlorocarbonylsulfenyl chloride as a carbonylating agent. It comprises the reaction of secondary amines with chlorocarbonylsulfenyl chloride in the presence of an aprotic organic solvent to produce the corresponding N, N-disubstituted carbamoyl halides. Insertion of the carbonyl group without using phosgene is the novelty of this method.