We report on the enzymatic hydrolysis of methyl 2-phenoxypropionate and of the following chlorinated derivatives: methyl o-chloro-, m-chloro-, p-chloro-, and o, p-dichloro-2- phenoxypropionates. α-Chymotrypsin, lipase, and pig liver esterase have an R enantioselectivity whereas subtilisin has an S enantioselectivity. Enantiomeric excesses (ee) cover a wide range (from 5 to 100%).