Synthesis of α??Amino Nitriles from Carbonyl Compounds, Amines, and Trimethylsilyl Cyanide: Comparison between Catalyst??Free Conditions and the Presence of Tin …

J Wang, Y Masui, M Onaka

Index: Wang, Jiacheng; Masui, Yoichi; Onaka, Makoto European Journal of Organic Chemistry, 2010 , # 9 p. 1763 - 1771

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Citation Number: 5

Abstract

Abstract In the absence of catalysts, the three-component, one-pot synthesis of α-amino nitriles proceeded using various aldehydes and ketones together with amines and trimethylsilyl cyanide (TMSCN) in high yields under neat conditions at room temperature. The addition order of the reagents had a significant influence on the yields of the desired α- amino nitriles. In contrast, when tin ion-exchanged montmorillonite (Sn-Mont), prepared by ...