Tetrahedron

The total synthesis of pamamycin-607. Part 2: Synthesis of the C6–C18 domain

BH Fraser, RJ Mulder, P Perlmutter

Index: Fraser, Benjamin H.; Mulder, Roger J.; Perlmutter, Patrick Tetrahedron, 2006 , vol. 62, # 12 p. 2857 - 2867

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Citation Number: 12

Abstract

Synthesis of the C6–C18 domain of pamamycin-607 was achieved in ten steps and 7% overall yield from commercially available d-norvaline. The key asymmetric transformations included a Paterson anti aldol addition, an anti selective reduction of the resultant β-hydroxy ketone and a cis selective Bartlett type ring closure.