Controlled synthesis of peptides in aqueous medium. VIII. Preparation and use of novel. alpha.-amino acid N-carboxyanhydrides

R Hirschmann, H Schwam, RG Strachan…

Index: Hirschmann; Schwam; Strachan; Schoenewaldt; Barkemeyer; Miller; Conn; Garsky; Veber; Denkewalter Journal of the American Chemical Society, 1971 , vol. 93, # 11 p. 2746 - 2754

Full Text: HTML

Citation Number: 80

Abstract

Abstract: The preparation of the crystalline a-amino acid N-carboxyanhydrides (Leuchs' anhydrides, NCA's) of the following amino acids is described: aspartic acid, asparagine, glutamine, 0-trimethylsilylserine, O-trimethylsilylthreonine, 0-trichloroacetylserine, histidine hydrobromide, 6-N-tert-butyloxycarbonyllysine, 0-(2-tetrahydropyrany1) tyrosine. All of these NCA's, except those of histidine and of 0-trichloroacetylserine, were shown to be useful in ...