Co-existence of α-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development

…, A Aoyama, T Noguchi-Yachide, M Makishima…

Index: Dodo, Kosuke; Aoyama, Atsushi; Noguchi-Yachide, Tomomi; Makishima, Makoto; Miyachi, Hiroyuki; Hashimoto, Yuichi Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4272 - 4285

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Citation Number: 31

Abstract

Liver X receptors (LXR), which were originally reported as oxysterol-activated nuclear receptors, were recently found to recognize glucose as a physiological ligand. On this basis, we have already developed novel LXR antagonists based upon α-glucosidase inhibitors derived from thalidomide. Here, to clarify the relationship between α-glucosidase inhibition and LXR modulation, we investigate the α-glucosidase-inhibitory activity of typical LXR ...