Synthesis of 1, 4-diketones by oxidative coupling of ketone enolates with copper (II) chloride

Y Ito, T Konoike, T Harada…

Index: Ito,Y. et al. Journal of the American Chemical Society, 1977 , vol. 99, p. 1487 - 1493

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Citation Number: 165

Abstract

Abstract: A full scope of oxidative coupling of lithium enolates providing a general and efficient preparation of 1, 4-diketones was examined. The oxidative coupling of lithium enolates was performed by treating ketone enolates, which were prepared from ketone and lithium diisopropylamide in THF at-78 OC, with CuCl2 in DMF. The use of DMF cosolvent was very crucial in the copper promoted oxidative coupling of lithium enolates. Methyl ...