Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding

N Chauret, D Guay, C Li, S Day, J Silva…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 16 p. 2149 - 2152

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Citation Number: 29

Abstract

... JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. Volume 12, Issue 16, 19 August 2002, Pages 2149–2152. Cover image Cover image. ...

Design and Synthesis of Conformationally Constrained Analogs...

[Brackeen, Marcus F.; Cowan, David J.; Stafford, Jeffrey A.; Schoenen, Frank J.; Veal, James M.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4848 - 4854]

Improvement of therapeutic index of phosphodiesterase type I...

[Kim, Euikyung; Chun, Hyung-Ok; Jung, Sung-Hak; Kim, Jong Hoon; Lee, Jae-Mok; Suh, Byung-Chul; Xiang, Myung Xik; Rhee, Chung K. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2355 - 2358]

Discovery of L-791,943: a potent, selective, non emetic and ...

[Bioorganic and medicinal chemistry letters, , vol. 12, # 11 p. 1457 - 1461]