Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore

…, WF DeGrado, JG Saven, MJ Therien

Index: Ishizuka, Tomoya; Sinks, Louise E.; Song, Kai; Hung, Sheng-Ting; Nayak, Animesh; Clays, Koen; Therien, Michael J. Journal of the American Chemical Society, 2011 , vol. 133, # 9 p. 2884 - 2896

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Citation Number: 21

Abstract

This work reports the first example of a single-chain protein computationally designed to contain four α-helical segments and fold to form a four-helix bundle encapsulating a supramolecular abiological chromophore that possesses exceptional nonlinear optical properties. The 109-residue protein, designated SCRPZ-1, binds and disperses an insoluble hyperpolarizable chromophore, ruthenium (II)[5-(4′-ethynyl-(2, 2′; 6′, 2 ″-terpyridinyl) ...