Synthesis

Optimisation of the synthesis of guanidines from amines via nitroguanidines using 3, 5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine

JA Castillo-Meléndez, BT Golding

Index: Castillo-Melendez, Joel A.; Golding, Bernard T. Synthesis, 2004 , # 10 p. 1655 - 1663

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Citation Number: 23

Abstract

Abstract The synthesis of the useful reagent for the preparation of guanidines, 3, 5-dimethyl- N-nitro-1-pyrazole-1-carboxamidine (DMNPC), has been optimised. A detailed protocol for using this reagent for the preparation in pure form of a range of guanidines via nitroguanidines is described. A comparison has been made regarding efficiency between DMNPC and the guanidinylating reagents N, N′-bis-Boc-1-pyrazole-1-carboxamidine (2) ...