Journal of the American Chemical Society

Reduction of Lactones to Hydroxyaldehydes with Lithium Aluminum Hydride

GE Arth

Index: Arth Journal of the American Chemical Society, 1953 , vol. 75, p. 2413

Full Text: HTML

Citation Number: 21

Abstract

Hexoses have been prepared in a practical manner by the partial reduction of polyhydroxy-y- lactones with sodium amalgam1 This partial reduction fails when applied to non- hydroxylated lactones. 2 Lithium aluminum hydride3 in excess reduces saturated y-and &lactones to 1, 4-and 1, 5-diols, respectively. The same reagent is reported4 to reduce a- angelica lactone to y-acetopropanol and P-angelica lactone to the diol. In 1949, ...