Quinolines. V. Some Polysubstituted 4-(4'-Diethylamino-1'-methylbutylamino)-quinolines1

EA Steck, LL Hallock, AJ Holland…

Index: Steck et al. Journal of the American Chemical Society, 1948 , vol. 70, p. 1012,1014

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Citation Number: 13

Abstract

Chloroquine (SN 7618, 7-chloro-4-(4 '-diethylamino-1-methylbutylamino)-quinoline) 2, 8 has been found to be the most effective of the quinoline antimalarials bearing the basic chain in position 4. In our program, which has involved the preparation of numerous analogous compounds bearing an alkyl group in the pyridine m~ iety,~ we have attempted to evaluate the influence of the position and nature of several groups upon antiplasmodial activity. ...