Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors

…, X Siomboing, S Yous, B Gressier, M Luyckx…

Index: Park, Chang Ha; Siomboing, Xavier; Yous, Said; Gressier, Bernard; Luyckx, Michel; Chavatte, Philippe European Journal of Medicinal Chemistry, 2002 , vol. 37, # 6 p. 461 - 468

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Citation Number: 28

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen or indomethacin are widely used in the treatment of pain and inflammatory diseases [1]. Their clinical efficacy is closely related to their ability to inhibit both COX-1 and COX-2 isoforms of the enzyme cyclooxygenase (COX) also referred to as prostaglandin H 2 synthase since it catalyses the conversion of arachidonic acid to prostaglandin H 2 (PGH 2 ) [2]. The constitutive COX-1 isoform is mainly ...