Tetrahedron

Total synthesis of cyercene A and the biomimetic synthesis of (±)-9, 10-deoxytridachione and (±)-ocellapyrone A

R Rodriguez, RM Adlington, SJ Eade, MW Walter…

Index: Rodriguez, Raphael; Adlington, Robert M.; Eade, Serena J.; Walter, Magnus W.; Baldwin, Jack E.; Moses, John E. Tetrahedron, 2007 , vol. 63, # 21 p. 4500 - 4509

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Citation Number: 21

Abstract

This paper summarises our detailed study towards the biomimetic synthesis of the complex polypropionate derived natural product (±)-9, 10-deoxytridachione. A previous study based on the elaboration of functionalised γ-pyrones allowed us to synthesise cyercene A. The same efficient methodology has been applied for the elaboration of a more complex fully conjugated γ-pyrone polyene. Our approach centred on a key tandem Suzuki-coupling/ ...