Tetrahedron Letters

A cross-linked polystyrene supported hindered lithium amide as a deprotonation reagent for α-methylation of lactic acid

K Watanabe, Y Andou, Y Shirai, H Nishida

Index: Watanabe, Kohtaro; Andou, Yoshito; Shirai, Yoshihito; Nishida, Haruo Tetrahedron Letters, 2013 , vol. 54, # 32 p. 4320 - 4323

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Abstract

The poly (tetramethylglycolide)[PTMG] is currently attracting a lot of interest as an upgraded feedstock recyclable material derived from poly (l-lactic acid). To achieve more efficient process of PTMG production from lactic acid, hindered lithium amide supported by cross- linked polystyrene as a deprotonation reagent was prepared from commercially available Merrifield resin, 2, 2, 6, 6-tetramethyl-4-pipedinol, and n-butyllithium. A polymer-supported ...