Synthesis of C-8 alkylamino substituted pyrrolo [2, 1-c][1, 4] benzodiazepines as potential anti-cancer agents

…, N Laxman, G Ramesh, O Srinivas, P Ramulu

Index: Kamal, Ahmed; Laxman; Ramesh; Srinivas; Ramulu Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 15 p. 1917 - 1919

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Citation Number: 26

Abstract

The design and facile synthesis of C-8 alkylamino substituted pyrrolo [2, 1-c][1, 4] benzodiazepines is described. These have been prepared by linking the amines at C-8 position with propane spacer to improve solubility in water, and their in vitro cytotoxicity studies have been carried out.