Pyridine derivatives possessing hypoglycemic and analgesic activity

…, GV Pesotskaya, ES Levchenko, SE Mogilevich…

Index: Slyusarenko, E. I.; Gorodetskova, N. P.; Pesotskaya, G. V.; Levchenko, E. S.; Mogilevich, S. E.; Luk'yanchuk, V. D. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 9 p. 739 - 743 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 9 p. 1076 - 1080

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Abstract

It was found that urea derivatives I and II are easily formed in the reaction of N- monochloramides of nicotinic and isonicotinic acids, respectively, with ammonia (cf.[11]). The reaction of ureas I and II with methyl iodide produce (l-methyl-pyridinium-3)-urea iodide (III) and (lmethylpyridinium-4)-urea iodide (IV). Analogously, l-methylpyridium-3-carbamide iodide (VI) is formed from nicotinamide (V) in the presence of methyl iodide.