e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Efficient One??Pot Four??Component Synthesis and X??ray Crystallographic Structure of 2??Pyridone Derivatives
S Balalaie, MM Hashemi, SH Khezri…
Index: Balalaie, Saeed; Hashemi, Mohammed M.; Khezri, S. Hadi; Rominger, Frank; Ghabraie, Elmira; Oeser, Thomas Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1272 - 1280
Abstract A series of 3-cyano-2-pyridone derivatives were synthesized by one-pot four- component condensation reaction involving a benzaldehyde derivative, alkyl cyanoacetate, acyclic or cyclic ketones, and ammonium acetate in reflux condition. The X-ray structure of the products 5a and 5d confirm symmetric dimers via hydrogen bonding interactions between individual pyridine molecules showing, in addition, also π–π stacking ...
