Tetrahedron

Sequential palladium-catalysed C-and N-arylation reactions as a practical and general protocol for the synthesis of the first series of oxcarbazepine analogues

M Carril, R SanMartin, E Domínguez, I Tellitu

Index: Carril, Monica; SanMartin, Raul; Dominguez, Esther; Tellitu, Imanol Tetrahedron, 2007 , vol. 63, # 3 p. 690 - 702

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Citation Number: 25

Abstract

The first series of oxcarbazepine analogues, starting from readily-available materials and through a high-yielding five-step sequence based on palladium catalysis, is reported. The so- obtained compounds incorporate not only a variety of substituents in both of the aryl rings comprising the framework of an oxcarbazepine, but also involve the more challenging palladium-catalysed coupling of a number of heteroaromatic substrates. The addition of ...