Journal of Fluorine Chemistry

An efficient synthesis of (Z)-γ-fluoroallylphosphonates using a base-promoted deconjugation of (E)-γ-fluorovinylphosphonates, and its utility as fluoroolefin-containing …

GB Hammond

Index: Hammond, Gerald B.; Demendonca, Daniel J. Journal of Fluorine Chemistry, 2000 , vol. 102, # 1-2 p. 189 - 197

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Citation Number: 13

Abstract

A three-step synthesis of γ-fluoroallylphosphonates starting with α, β-unsaturated aldehydes is described. Treatment with diethyl phosphite in the presence of KF gives α-hydroxyallyl phosphonate in excellent yield; DAST deoxofluorination produces the corresponding γ-