Chemistry of heterocyclic compounds. 55. Synthesis and conformational studies of substituted 1, 2-diaryl-and heteroarylbenzenes. Synthesis of …

GR Newkome, JM Roper…

Index: Newkome, George R.; Roper, Jerry M.; Robinson, Michael J. Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4380 - 4385

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Citation Number: 16

Abstract

The syntheses of 1, 2-bis (3-methylphenyl)-, 1-(6-methyl-2-pyridy1)-2-(3-methylphenyl)-, and 1, 2-bis (6-methyl-2-pyridy1) benzenes are described. The aryl and heteroaryl olefins were brominated and didehydrobrominated to give the corresponding acetylenes, which were treated with e-pyrone to generate. the respective ortho-substituted benzenes. The methyl substituents were oxidized with potassium permanganate to give, after esterification, the ...