Synthesis of 2-amino-6-(4-[11 C] methoxyphenylthio)-9-[2-(phosphonomethoxy) ethyl] purine bis (2, 2, 2-trifluoroethyl) ester as a novel potential PET gene reporter …

JQ Wang, X Fei, TA Gardner, GD Hutchins…

Index: Wang, Ji-Quan; Fei, Xiangshu; Gardner, Thomas A.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 549 - 556

Full Text: HTML

Citation Number: 14

Abstract

Acyclic nucleoside 2-amino-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy) ethyl] purine bis (2, 2, 2-trifluoroethyl) ester (ABE, 1) is a new hepatitis B virus (HBV) specific antiviral reagent and shows high anti-HBV activity. Carbon-11 labeled ABE may serve as a novel reporter probe for positron emission tomography (PET) to image HBV and herpes simplex virus thymidine kinase (HSV-tk) in cancers. The radiolabeling precursors 2-amino ...