Synthesis and antimicrobial activities of structurally novel S, S′-bis (heterosubstituted) disulfides

P Ramaraju, D Gergeres, E Turos, S Dickey…

Index: Ramaraju, Praveen; Gergeres, Danielle; Turos, Edward; Dickey, Sonja; Lim, Daniel V.; Thomas, John; Anderson, Burt Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3623 - 3631

Full Text: HTML

Citation Number: 2

Abstract

The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S, S′-bis (heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These ...