A range of macrocyclic thiophene-based Mannich bases containing 10–22-membered rings has been prepared. The starting materials for the synthesis were substances of the type ArO– Z–OAr (where Ar= 2-methoxycarbonyl-3-thienyl and Z= alkyl or heteroalkyl), which were made by the reaction of α, ω-dihalides or-bis (toluene-p-sulfonate) s with two moles of methyl 3-hydroxythiophene-2-carboxylate. Saponification and subsequent ...
[Barker, John M.; Chaffin, Julie D. E.; Halfpenny, Joan; Huddleston, Patrick R.; Tseki, Potlaki F. Journal of the Chemical Society, Chemical Communications, 1993 , # 23 p. 1733 - 1734]
