Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1, 2, 3-triazole ring side-armed with alkane spacers

…, TLN Reddy, S Pushpavalli, M Pal-Bhadra

Index: Kamal, Ahmed; Prabhakar; Janaki Ramaiah; Venkat Reddy; Ratna Reddy, Ch.; Mallareddy; Shankaraiah, Nagula; Lakshmi Narayan Reddy; Pushpavalli; Pal-Bhadra, Manika European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3820 - 3831

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Citation Number: 70

Abstract

Aiming to develop multitarget drugs for the anticancer treatment, a new class of chalcone- pyrrolo [2, 1-c][1, 4] benzodiazepine (PBD) conjugates linked through a 1, 2, 3-triazole moiety containing alkane spacers has been designed and synthesized. Combining these two core pharmacophore structures with modifications at A-C8/C-C2-position of PBD ring system yielded analogs with improved efficacy and have shown promising in vitro ...