e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Tetrahedron

Oxides of 3-methyl-1, 2, 4-benzotriazine

RH Atallah, MZ Nazer

Index: Atallah, Raja H.; Nazer, Musa Z. Tetrahedron, 1982 , vol. 38, # 12 p. 1793 - 1796

Full Text: HTML

Citation Number: 20

Abstract

The previously prepared 3-methyl-1, 2, 4-benzotriazine oxide1 is shown to be the 4-oxide 5. Synthesis and structures of other isomeric and related oxides are described. A modification of a previously described synthesis of 1, 2, 4-benzotriazines produces purer products in higher yields.

1,2,4-benzotriazine Structure

1,2,4-benzotriazine

~0%

1-oxido-1,2,4-benzotriazin-1-ium Structure

1-oxido-1,2,4-b...

1,2,4-benzotriazine-2-oxide Structure

1,2,4-benzotria...

Structure

~%

1-oxido-1,2,4-benzotriazin-1-ium Structure

1-oxido-1,2,4-b...

Diphenyl formazan Structure

Diphenyl formazan

~%

1-oxido-1,2,4-benzotriazin-1-ium Structure

1-oxido-1,2,4-b...

1,2,4-benzotriazine Structure

1,2,4-benzotriazine

~%

1H-Benzotriazole Structure

1H-Benzotriazole

1-oxido-1,2,4-benzotriazin-1-ium Structure

1-oxido-1,2,4-b...

Structure

~%

1H-Benzotriazole Structure

1H-Benzotriazole

N,N'-diphenyl-C-methylformazan Structure

N,N'-diphenyl-C...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

1,2,4-benzotriazine Structure

1,2,4-benzotriazine

~%

1H-Benzotriazole Structure

1H-Benzotriazole

1-oxido-1,2,4-benzotriazin-1-ium Structure

1-oxido-1,2,4-b...

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

3-methyl-1-oxido-1,2,4-benzotriazin-1-ium Structure

3-methyl-1-oxid...

Detail

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

3-methyl-1-oxido-1,2,4-benzotriazin-1-ium Structure

3-methyl-1-oxid...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

Diphenyl formazan Structure

Diphenyl formazan

~%

1H-Benzotriazole Structure

1H-Benzotriazole

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

2-Methyl-1H-benzo[d]imidazole Structure

2-Methyl-1H-ben...

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

Detail

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

2-Methyl-1H-benzo[d]imidazole Structure

2-Methyl-1H-ben...

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

Detail

Structure

~%

1,2,4-benzotriazine Structure

1,2,4-benzotriazine

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

3-methyl-1-oxido-1,2,4-benzotriazin-1-ium Structure

3-methyl-1-oxid...

Detail

Structure

~%

3-methyl-1-oxido-1,2,4-benzotriazin-4-ium 4-oxide Structure

3-methyl-1-oxid...

N,N'-diphenyl-C-methylformazan Structure

N,N'-diphenyl-C...

~%

3-methyl-1-oxido-1,2,4-benzotriazin-4-ium 4-oxide Structure

3-methyl-1-oxid...

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

2-Methyl-1H-benzo[d]imidazole Structure

2-Methyl-1H-ben...

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

Detail

N,N'-diphenyl-C-methylformazan Structure

N,N'-diphenyl-C...

~60%

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

Diazene, phenyl(phenyl(phenylhydrazono)methyl)- Structure

Diazene, phenyl...

~70%

3-Phenyl-benzo(1,2,4)triazine Structure

3-Phenyl-benzo(...

Structure

~%

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

N,N'-diphenyl-C-methylformazan Structure

N,N'-diphenyl-C...

~%

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

3-methyl-1-oxido-1,2,4-benzotriazin-1-ium Structure

3-methyl-1-oxid...

Detail

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

2-Methyl-1H-benzo[d]imidazole Structure

2-Methyl-1H-ben...

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

Detail

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

2-Methyl-1H-benzo[d]imidazole Structure

2-Methyl-1H-ben...

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

Detail

Structure

~%

3-methyl-1-oxido-1,2,4-benzotriazin-1-ium Structure

3-methyl-1-oxid...

N,N'-diphenyl-C-methylformazan Structure

N,N'-diphenyl-C...

~%

3-methyl-1-oxido-1,2,4-benzotriazin-1-ium Structure

3-methyl-1-oxid...

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

3-methyl-1-oxido-1,2,4-benzotriazin-1-ium Structure

3-methyl-1-oxid...

Detail

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

2-Methyl-1H-benzo[d]imidazole Structure

2-Methyl-1H-ben...

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

Detail

3-methyl-1-oxido-1,2,4-benzotriazin-4-ium 4-oxide Structure

3-methyl-1-oxid...

~%

3-methyl-1-oxido-1,2,4-benzotriazin-1-ium Structure

3-methyl-1-oxid...

1,2,4-Benzotriazine, 3-methyl- Structure

1,2,4-Benzotria...

~%

1H-Benzotriazole Structure

1H-Benzotriazole

2-Methyl-1H-benzo[d]imidazole Structure

2-Methyl-1H-ben...

3-methyl-2-oxido-1,2,4-benzotriazin-2-ium Structure

3-methyl-2-oxid...

Detail

Isotopic labeling experiments that elucidate the mechanism o...

[Boyd, Maruta; Hay, Michael P.; Boyd, Peter D. W. Magnetic Resonance in Chemistry, 2006 , vol. 44, # 10 p. 948 - 954]

Isotopic labeling experiments that elucidate the mechanism o...

[Boyd, Maruta; Hay, Michael P.; Boyd, Peter D. W. Magnetic Resonance in Chemistry, 2006 , vol. 44, # 10 p. 948 - 954]

Crossed and linked histories of tetrapyrrolic macrocycles an...

[Robbins; Schofield Journal of the Chemical Society, 1957 , p. 3186,3191]

Crossed and linked histories of tetrapyrrolic macrocycles an...

[Robbins; Schofield Journal of the Chemical Society, 1957 , p. 3186,3191]

Crossed and linked histories of tetrapyrrolic macrocycles an...

[Robbins; Schofield Journal of the Chemical Society, 1957 , p. 3186,3191]