Tetrahedron letters

Addition of α-halonitriles to carbonyl compounds catalyzed by zinc-trimethylchlorosilane: A general synthesis of β-trimethylsilyloxy nitriles

C Palomo, JM Aizpurua, MC López, N Aurrekoetxea

Index: Palomo, Claudio; Aizpurua, Jesus M.; Lopez, M. Concepcion; Aurrekoetxea, Natalia Tetrahedron Letters, 1990 , vol. 31, # 15 p. 2205 - 2208

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Citation Number: 21

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Reaction between bromoacetonitrile and carbonyl compounds in the presence of zinc and trimethylchlorosilane produced β-trimethylsilyloxynitriles in excellent yields. The reaction also works well with chloroacetonitrile as source of cyanomethyl carbanion. ... Reaction between bromoacetonitrile or ...