Chemical Communications

Enantioselective bromolactonization of cis-1, 2-disubstituted olefinic acids using an amino-thiocarbamate catalyst

CK Tan, C Le, YY Yeung

Index: Tan, Chong Kiat; Le, Chencheng; Yeung, Ying-Yeung Chemical Communications, 2012 , vol. 48, # 46 p. 5793 - 5795

Full Text: HTML

Citation Number: 60

Abstract

A facile, highly regio-and enantioselective amino-thiocarbamate-catalyzed bromolactonization of cis-1, 2-disubstituted olefinic acids has been developed. The use of the enantio-enriched lactones in the synthesis of chiral synthetic intermediates is also demonstrated.