Substituted cinnamoyl chlorides, 11, were converted into (2-hydroxyethyl)-oxazolinium chlorides 14, N, N-bis-(2-chloroethyl) amides 16 and (2-chloroethyl)-oxazolinium chlorides 17. Although derivatives 14 which possess electron-donating substituents (Me or MeO) were more potent than those substituted by electron-withdrawing groups (NO2, Cl or CF3), the difference in cytotoxic actin was not significant. Modification of the lipophilic character in a ...
