Synthesis of arylbromides from arenes and N-bromosuccinimide (NBS) in acetonitrile-A convenient method for aromatic bromination

E Zysman-Colman, K Arias…

Index: Zysman-Colman, Eli; Arias, Karla; Siegel, Jay S. Canadian Journal of Chemistry, 2009 , vol. 87, # 2 p. 440 - 447

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Citation Number: 33

Abstract

Regioselective and chemoselective electrophilic bromination of a wide series of activated arenes using N-bromosuccinimide (NBS) in acetonitrile occurs readily. Environmentally friendly conditions, large substrate scope, and ease of synthesis enhance the utility of this method over other electrophilic bromination conditions.

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