11 work in construction of the oxazolone ring at a late stage in the synthesis? & In addition, this approach would make possible the synthesis of benzo-substituted analogues not readily available via the published procedures, and would also allow preparation of 2-amino analogues of the parent antibiotic via the amine exchange reaction.
[Witty, David R.; Walker, Graham; Bateson, John H.; O'Hanlon, Peter J.; Cassels, Robert Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 12 p. 1375 - 1380]
