General method of preparation of N-[(S)-(3-hydroxy-2-phosphonomethoxypropyl)] derivatives of heterocyclic bases

P Alexander, A Holý

Index: Alexander, Petr; Holy, Antonin Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, p. 1151 - 1163

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Citation Number: 8

Abstract

Abstract Reaction of (R)-1-Op-toluenesulfonyl-1, 2, 3-propanetriol (IV) with N- trimethylacetylimidazole (II) afforded (R)-1-Op-toluenesulfonyl-3-O-trimethyacetyl-1, 2, 3- propanetriol (V) which was reacted with dimethoxymethane in the presence of phosphorus pentoxide to give (R)-2-O-methoxymethyl-1-Op-toluenesulfonyl-3-O-trimethyacetyl-1, 2, 3- propanetriol (VI). Compound VI was treated with acetic anhydride and boron trifluoride ...