Synthesis of N-(protected) aminophthalimides: application to the synthesis of singly labelled isoniazid

N Brosse, MF Pinto, B Jamart-Grégoire

Index: Brosse, Nicolas; Pinto, Maria-Fatima; Jamart-Gregoire, Brigitte Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3685 - 3688

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Citation Number: 22

Abstract

The synthesis of a series of N-(protected) aminophthalimides and the removal of their phthaloyl group leading to N-(protected) or N, N-bis (protected) hydrazines is described. As illustrated by the synthesis of monolabelled isoniazid 3b*, this strategy can be utilized for the preparation of monolabelled substituted hydrazines.

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