Organic letters

Stereoselective Aldol Reaction of Glutarimides Using Pseudo C 2 Symmetry

Y Watanabe, T Yamazaki, T Kubota

Index: Watanabe, Yohsuke; Yamazaki, Takashi; Kubota, Toshio Organic Letters, 2010 , vol. 12, # 2 p. 268 - 271

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Citation Number: 2

Abstract

In recent years, trifluoromethyl-containing compounds have been growing in importance and value because of their strategic applications in the medicinal and functional materials fields.(1) We have pursued the development of the syntheses of chiral CF 3 -containing compounds by use of desymmetrization of β-CF 3 -substituted glutaric acid derivatives; their pseudo C 2 symmetry enables concomitant stereocontrol of two or three chiral centers by a single nucleophilic ...