Solvent dependence of oxygen isotope effects on the decarboxylation of 4-pyridylacetic acid

GW Headley, MH O'Leary

Index: Headley, George W.; O'Leary, Marion H. Journal of the American Chemical Society, 1990 , vol. 112, # 5 p. 1894 - 1896

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Citation Number: 15

Abstract

AbshPct Oxygen isotope. effects on the decarboxylation of Cpyridylacetic acid have been measured by the remote-label technique. The isotope effect varies from kI6/k'*= 0.995 per oxygen in 25% dioxane to 1.003 in 75% dioxane. The isotope effect reflects three contributions: An inverse isotope effect of 0.98-0.99 due to the change in carbon-oxygen bond order on going from ground state to transition state, an effect of 1.01-1.02 due to ...