Synthesis, dopamine D 2 receptor binding studies and docking analysis of 5-[3-(4-arylpiperazin-1-yl) propyl]-1H-benzimidazole, 5-[2-(4-arylpiperazin-1-yl) ethoxy]-1H- …

…, S Kostić-Rajačić, A Schrattenholz, V Šoškić

Index: Sukalovic; Andric, Deana; Roglic; Kostic-Rajacic, Sladjana; Schrattenholz; Soskic European Journal of Medicinal Chemistry, 2005 , vol. 40, # 5 p. 481 - 493

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Citation Number: 32

Abstract

5-[3-(4-Arylpiperazin-1-yl) propyl]-1H-benzimidazoles and 5-[2-(4-arylpiperazin-1-yl) ethoxy]- 1H-benzimidazoles were synthesized and their affinity for the D1, D2 and 5-HT1A receptors examined. They expressed a rather high affinity for the D2 dopamine receptor. The main features of ligand–D2 receptor interactions revealed by docking analyses were: salt bridge between piperazine ring protonated N1 and Asp 86, hydrogen bonds of ligand ...