Abstract Antibody catalysts for the removal of the p-nitrobenzyl ester protecting group have been generated to accommodate a broad range of substrates. Antibody 7B9, which was elicited against p-nitrobenzyl phosphonate 1, catalyzed the hydrolyses of p-nitrobenzyl monoesters of nonsubstituted, and β-and γ-substituted glutaric acids with almost identical K m and k cat values. In addition, 7B9 displayed substrate tolerance towards the α- ...
