Abstract Fragment-based drug discovery has gained a foothold in today's lead identification processes. We present the application of in silico fragment-based screening for the discovery of novel lead compounds for the metalloendoproteinase thermolysin. We have chosen thermolysin to validate our screening approach as it is a well-studied enzyme and serves as a model system for other proteases. A protein-targeted virtual library was ...
![methyl 2-[(1-oxopropyl)amino]benzoate Structure](https://image.chemsrc.com/caspic/101/25628-84-6.png)