Liebigs Annalen der Chemie

Über die Synthese von 2′, 3′??Didesoxy??3′??(phosphonomethyl) nucleosiden, Phosphonat??Analogen von 2′??Desoxy??3′??nucleotiden

M Morr, L Ernst, D Schomburg

Index: Morr, Michael; Ernst, Ludger; Schomburg, Dietmar Liebigs Annalen der Chemie, 1991 , # 7 p. 615 - 631

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Citation Number: 8

Abstract

1, 2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-(diethoxyphosphoryl-methyl)-PD-ribofuranose (8) is linked (a) to the protected pu-rine bases AB”, GiB and T, respectively, in the presence of potassium nonaflate and (b) to the silylated pyrimidine bases C, U and UF (= 5-fluoro-U) according to the Hilbert-Johnson method by using stannic tetrachloride. Selective 2 '-O- deacetylation by hydroxylammonium acetate or hydrazine hydrate employing Ishido's ...