Synthesis and antibacterial activity of cephalosporins having hydroxamic acid at C-7 position

MG Kim, JC Jung, MJ Sung, YK Choi, SG An…

Index: Kim, Myoung Goo; Jung, Jae Chul; Sung, Moo Je; Choi, Young Key; An, Sang Geun; Lee, Se-Jong; Yoon, Geal-Jung; Park, Myung Hwan Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 17 p. 2077 - 2080

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Citation Number: 9

Abstract

The synthesis and in vitro activity of cephalosporins with hydroxamic acid at the 7-position are described. Anti-pseudomonal activity of the compound 11a was shown to be comparable to that of ceftazidime. Especially, the compound 11a exhibited good activity against Gram-positive bacteria including Streptococcus pneumoniae and Staphylococcus aureus.