New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages

T Honda, HJ Finlay, GW Gribble, N Suh…

Index: Honda, Tadashi; Finlay, Heather J.; Gribble, Gordon W.; Suh, Nanjoo; Sporn, Michael B. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1623 - 1628

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Citation Number: 106

Abstract

New derivatives of 3-oxoolean-1-en-28-oic acid and 3-oxours-1-en-28-oic acid were synthesized. Nine of them showed significant inhibitory activity against interferon-γ-induced nitric oxide production in mouse macrophages when assayed at the 1 μM level. 3, 12- Dioxoolean-1, 9-dien-28-oic acid (3) had the highest activity (IC50, 0.9 μM).