Inhibitors of pancreatic and leukocyte elastase

E Kasafírek, P Frič, J Slabý…

Index: Kasafirek, Evzen; Fric, Premysl; Slaby, Jan; Kocna, Petr Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 12 p. 3034 - 3041

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Citation Number: 4

Abstract

Abstract The following alkylamides of ω-carboxyalkanoyldi-and tripeptides of the Ala-Pro or Ala-Ala-Pro sequence have been prepared: ethylamide-, propylamide-, and isobutylamide of 3-carboxypropionylalanyl-proline, ethylamide of 3-carboxypropionylalanyl-alanyl-proline and ethylamide-, propylamide, and isobutylamide of 4-carboxybutyrylalanyl-alanyl-proline. The inhibitors were synthesized by fragment condensation in solution or by gradual ...