Biochemistry

Identification of structural–kinetic and structural–thermodynamic relationships for thrombin inhibitors

J Winquist, S Geschwindner, Y Xue, L Gustavsson…

Index: Nilsson, Mikael; Haemaelaeinen, Markku; Ivarsson, Maria; Gottfries, Johan; Xue, Yafeng; Hansson, Sebastian; Isaksson, Roland; Fex, Tomas Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 2708 - 2715

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Citation Number: 14

Abstract

To improve our understanding of drug–target interactions, we explored the effect of introducing substituted amine residues with increased chain length in the P3 residue of the thrombin inhibitor melagatran. Inhibition, kinetic, and thermodynamic data obtained via

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