Sex differences in the metabolism of (+)-and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome P450 enzymes in rat liver microsomes

M Miyazawa, M Shindo, T Shimada

Index: Miyazawa, Mitsuo; Shindo, Masaki; Shimada, Tsutomu Chemical Research in Toxicology, 2002 , vol. 15, # 1 p. 15 - 20

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Citation Number: 38

Abstract

(+)-Limonene is reported to cause nephropathy in male rats, but not in female rats and other species of animals including mice, rabbits, guinea pigs, and dogs. Male rats contain high levels of α 2u-globulin in kidneys, and it has been shown that limonene and/or its ...

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