Weakening C− O Bonds: Ti (III), a New Reagent for Alcohol Deoxygenation and Carbonyl Coupling Olefination

…, MM Herrador, JF Quilez del Moral…

Index: Barrero, Alejandro F.; Herrador, M. Mar; Quilez Del Moral, Jose F.; Arteaga, Pilar; Arteaga, Jesus F.; Dieguez, Horacio R.; Sanchez, Elena M. Journal of Organic Chemistry, 2007 , vol. 72, # 8 p. 2988 - 2995

Full Text: HTML

Citation Number: 49

Abstract

Investigations detailed herein, including density functional theory (DFT) calculations, demonstrate that the formation of either alkoxy− or hydroxy− Ti (III) complexes considerably decreases the energy of activation for C− O bond homolysis. As a consequence of this observation, we described two new synthetic applications of Nugent's reagent in organic chemistry. The first of these applications is an one-step methodology for deoxygenation− ...