Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids

RA Appleton, JR Bantick, TR Chamberlain…

Index: Appleton,R.A. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 371 - 379

Full Text: HTML

Citation Number: 67

Abstract

prepared by the method of Richter and Fuller: mp 274-277" C (lit. 13 278-279" C). 2, 6-(and 2, 8-) Bis (chloroacety1) dibenzothiophene (70). A solution of 50.0 g (0.27 mol) of dibenzothiophene and 77.0 g (0.68 mol) of chloroacetyl chloride in 400 ml of CHzClz was chilled to-20" C and 76.5 g (0.572 mol) of A1C13 was added with rapid stirring. Stirring at room temperature was continued for 16 h and then the reaction was poured onto ice- ...

 Related Synthetic Route

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%