An Approach to 2, 4??Substituted Pyrazolo [1, 5??a] pyridines and Pyrazolo [1, 5??a] azepines by Ring??Closing Metathesis

…, A Asensio, MA Maestro, JL Aceña…

Index: Fustero, Santos; Roman, Raquel; Asensio, Amparo; Maestro, Miguel A.; Acena, Jose L.; Simon-Fuentes, Antonio European Journal of Organic Chemistry, 2013 , # 31 p. 7164 - 7174

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Citation Number: 3

Abstract

Abstract The ring-closing metathesis (RCM) reactions of dienylpyrazoles have been employed in the synthesis of pyrazolo [1, 5-a] pyridine and pyrazolo [1, 5-a] azepine derivatives. Based on this approach, the diastereoselective synthesis of potential peptidomimetics containing four amino acid residues with the second (i+ 1) and third (i+ 2) fragments having been substituted by bicyclic frameworks is described.