… Agonists to Antagonists in the Synthesis of New 5??Hydroxytryptamine (5??HT3) Receptor Antagonists and Preliminary In??vitro Pharmacological Evaluation on Guinea?? …

…, AR Subramanian, SAV Raghavan…

Index: Srinivas; Subramanian; Raghavan; Babu, R. Jagadeesh; Gupta; Sridhar; Veeranjaneyulu; Parimoo Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 2 p. 95 - 101

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Citation Number: 4

Abstract

Abstract Structural variations from agonists to their selective antagonists follow specific patterns. These patterns in reported molecules or drugs were analysed and common variation patterns, as possible principles to design new antagonistic drugs, were studied. The generalized structural modification patterns were successfully applied as guiding principles to synthesize two series of compounds with 5-hydroxytryptamine (5-HT 3) ...