Pharmacological Studies of 1??(p??Chlorophenyl) propanol and 2??(1??Hydroxy??3??butenyl) phenol: Two New Non??narcotic Analgesics Designed by Molecular …

…, R GARCÍA??DOMENECH, J Galvez…

Index: Garcia-March; Garcia-Domenech; Galvez; Anton-Fos; De Julian-Ortiz; Giner-Pons; Recio-Iglesias Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 1 p. 10 - 15

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Citation Number: 11

Abstract

Abstract Molecular topology has been applied to the design of new analgesic drugs. Linear discriminant analysis and connectivity functions were used to design two potentially suitable drugs which were synthesized and tested for analgesic properties by the acetic acid-induced abdominal constriction test in mice and the tail-flick test in rats.