Tetrahedron Letters

Application of flow chemistry to the reduction of nitriles to aldehydes

JM Muñoz, J Alcázar, A de la Hoz, A Díaz-Ortiz

Index: Munoz, Juan De M.; Alcazar, Jesus; De La Antonio, Hoz; Diaz-Ortiz, Angel Tetrahedron Letters, 2011 , vol. 52, # 46 p. 6058 - 6060

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Citation Number: 6

Abstract

Reduction of nitriles to aldehydes with diisobutylaluminium hydride (DIBAL-H) is an important transformation in organic chemistry. But the use of this reaction is limited for the lack of reproducibility due to the instability of the intermediates formed. In the current article we disclose the improvement of the reaction applying continuous flow technology.